Nicotinamide attenuates the ischemic brain injury-induced decrease of Akt activation and Bad phosphorylation

► Nicotinamide protects brain tissues against cerebral ischemic injury. ► Nicotinamide prevents brain injury-induced decrease of phospho-Akt and phospho-Bad. ► Nicotinamide prevents brain injury-induced reduction of phospho-Bad and 14-3-3 interaction.