کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4345323 1296723 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Induction of Per1 expression following an experimentally induced epilepsy in the mouse hippocampus
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Induction of Per1 expression following an experimentally induced epilepsy in the mouse hippocampus
چکیده انگلیسی

The Period1 (Per1) is a clock-oscillating gene product that plays an essential role in the generation and modulation of circadian rhythm in the suprachiasmatic nucleus (SCN) of hypothalamus. However, Per1 is also expressed in many other brain regions including cerebral cortex, hippocampus, and amygdala, suggesting that Per1 may be involved in the broader cellular functions in addition to the rhythm regulation. In this study, we found that chemical or electrical seizure-inducing stimulations regulate Per1 expression. Treatments with electric convulsive shock (ECS) or kainic acid (KA) robustly up-regulated the expressions of per1 mRNA and protein in the hippocampal formation and cerebral cortex. In consistent, we found that neuronal depolarization or KA treatment increased per1 mRNA expression in cultured primary cortical neurons. Because it has been demonstrated that Per family molecules contribute to the regulation of stress-induced cell death, we also explored the effect of Per1 overexpression on the survival of cultured neurons. However, neither basal, staurosporine- nor KA-induced neuronal death was affected by forced expression of Per1. Collectively, these results suggest that the Per1 expression is neuronal activity- and epileptogen-dependent, although its functional significance is remained to be explored.


► Epileptogenic conditions increase Per1 expression in the hippocampus.
► Neuronal depolarization increases Per1 expression in cultured neurons.
► Overexpression of Per1 does not influence the neuronal survival.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 498, Issue 2, 8 July 2011, Pages 110–113
نویسندگان
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