Minocycline injection in the ventral posterolateral thalamus reverses microglial reactivity and thermal hyperalgesia secondary to sciatic neuropathy

► Peripheral nerve injury favors a hyperactive phenotype of microglia in the VPL. ► Remote neuroimmune signaling from the damaged peripheral nerve to the brain. ► Neuropathic behavior is reversed by local intervention in the VPL for the inhibition of microglia.