An inhibitor of cAMP-dependent protein kinase induces behavioural and neurological antidepressant-like effects in rats

► Rp-8-Br-cAMPS (a selective inhibitor of protein kinase A) acts antidepressant-like in the rat forced swim test. ► Rp-8-Br-cAMPS increases cerebellar CREB phosphorylation. ► Rp-8-Br-cAMPS increases cAMP and cGMP in several brain areas. ► The antidepressant-like effects of this drug may be mediated by a PKA-independent mechanism(s) such as Epac.