Reactivation of visual cortical plasticity by NEP1-40 from early monocular deprivation in adult rats

► NEP1-40 blocks the NgR and its downstream pathways. ► NEP1-40 increases the dendritic spine density in adult monocular deprivation rats. ► NEP1-40 reactivates the synaptic plasticity in adult monocular deprivation rats. ► NEP1-40 recovers the objective visual function in adult monocular deprivation rats.