Spinal cord histopathology of MOG peptide 35-55-induced experimental autoimmune encephalomyelitis is time- and score-dependent

► CNS histopathology mirrors the hallmarks of MS. ► There is a stage-dependent transition from inflammation to neurodegeneration. ► Clinical disease severity correlates strongly with the extent of white matter plaque formation. ► Our data reinforce the importance of the MOG peptide 35-55 model for structural studies of MS.