Human clinical trails in antiepileptogenesis

Blocking the development of epilepsy (epileptogenesis) is a fundamental research area with the potential to provide large benefits to patients by avoiding the medical and social consequences that occur with epilepsy and lifelong therapy. Human clinical trials attempting to prevent epilepsy (antiepileptogenesis) have been few and universally unsuccessful to date. In this article, we review data about possible pathophysiological mechanisms underlying epileptogenesis, discuss potential interventions, and summarize prior antiepileptogenesis trials. Elements of ideal trials designs for successful antiepileptogenic intervention are suggested.

► Blocking epileptogenesis in those at risk is critical for controlling this serious disorder.
► Animal models are beginning to demonstrate that this can be done although much more research is needed in this area.
► Human trials to date have been unsuccessful.
► Designing clinical trials for epileptogenesis is challenging and requires more research.