Heat shock protein 72 (Hsp72) improves long term recovery after focal cerebral ischemia in mice

Many brain protective strategies have been tested over short survival intervals, but few have been examined for long term benefit. The inducible member of the Heat shock protein 70 (Hsp70) family, Heat shock protein 72 (Hsp72), has been widely found to reduce ischemic injury. Here we assessed outcome in Hsp72 transgenic overexpressing mice and wild type littermates for one month following transient focal ischemia. Hsp72 reduced infarct area lost and improved behavioral outcome on rotarod and foot fault at one month. Thus protection by Hsp72 overexpression is long lasting, and includes improved recovery of motor function over one month.

Research highlights▶ Hsp72 is a chaperone widely studied for its protective properties. ▶ Transgenic mice overexpressing Hsp72 are protected from brain loss due to stroke. ▶ Hsp72 mice recover motor function back to baseline over 28 days. WT do not.