Methionine diet-induced hyperhomocysteinemia accelerates cerebral aneurysm formation in rats

► Methionine-rich water induces hyperhomocysteinemia (HHcy) in rats. ► HHcy contributes to CA formation. ► CA formation is accelerated by methionine diet-induced HHcy. ► CA formation is associated with high expression of proinflammatory genes. ► CA formation is associated with high expression of vascular modifying genes.