High cerebrospinal tau levels are associated with the rs242557 tau gene variant and low cerebrospinal β-amyloid in Parkinson disease

▶ A polymorphism in the tau gene affects the CSF levels of tau and phospho-tau in PD. ▶ This effect is dependent on the presence of dementia and low CSF β-amyloid levels. ▶ Such AD-like gene-CSF endophenotypes may have therapeutic relevance in the future.