Anxiety-like behavior in the elevated-plus maze tests and enhanced IL-1β, IL-6, NADPH oxidase-1, and iNOS mRNAs in the hippocampus during early stage of adjuvant arthritis in rats

▶ Early adjuvant arthritis (AA) induces anxiety, and affects locomotor. ▶ Early AA upregulates mRNAs for IL-1β, IL-6, iNOS, NAPDH oxidase1 in hippocampus. ▶ Early AA triggers oxidative stress in hippocampus and impairs behavior.