Early impact of 5-HTTLPR polymorphism on the neural correlates of sadness

▶ Impact of the short (S) allele of the serotonin transporter gene linked polymorphism. ▶ Brain activity measured (with fMRI) in children during transient sadness. ▶ Abnormal pattern of regional brain activity in children carrying the S allele. ▶ The S allele may increase susceptibility to depressive symptoms.