کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4345694 1296748 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Apamin, a selective blocker of SKCa channels, inhibits posthypoxic hyperexcitability but does not affect rapid hypoxic preconditioning in hippocampal CA1 pyramidal neurons in vitro
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Apamin, a selective blocker of SKCa channels, inhibits posthypoxic hyperexcitability but does not affect rapid hypoxic preconditioning in hippocampal CA1 pyramidal neurons in vitro
چکیده انگلیسی

The aim of this study was to investigate the effects of apamin, a selective blocker of SKCa channels, on the repeated brief hypoxia-induced posthypoxic hyperexcitability and rapid hypoxic preconditioning in hippocampal CA1 pyramidal neurons in vitro. The method of field potentials measurement in CA1 region of the rat hippocampal slices was used. Application of apamin (50 nM) to the hippocampal slices during hypoxic episodes significantly abolished posthypoxic hyperexcitability induced by brief hypoxic episodes. However, in contrast to our previous results with iberiotoxin, a selective blocker of BKCa channels, apamin significantly enhanced the depressive effect of brief hypoxia on the PS amplitude during hypoxic episode and did not abolish the rapid hypoxic preconditioning in CA1 pyramidal neurons. Present results indicate that SKCa channels, along with previously implicated BKCa channels, play an important role in the development of posthypoxic hyperexcitability induced by brief hypoxic episodes in CA1 pyramidal neurons. However, SKCa channels, in contrast to the BKCa channels, are not involved in the rapid hypoxic preconditioning in CA1 hippocampal region in vitro.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 484, Issue 1, 22 October 2010, Pages 35–38
نویسندگان
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