کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4345802 1296755 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Retinal blood vessels are damaged in a rat model of NMDA-induced retinal degeneration
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Retinal blood vessels are damaged in a rat model of NMDA-induced retinal degeneration
چکیده انگلیسی

Retinal ischemia–reperfusion causes capillary degeneration but the mechanisms of damage are not well understood. The NMDA receptor plays an important role in neuronal damage after ischemia–reperfusion. Therefore, we determined whether retinal blood vessels are damaged structurally and functionally in a rat model of retinal degeneration induced by NMDA. At 7 days after a single intravitreal injection of NMDA (200 nmol) into the eye, loss of retinal ganglion cells and thinning of the inner plexiform layer were observed. Endothelial cells disappeared in some regressing vessels and empty basement membrane sleeves were left as remnants of the vessels. The number of basement membrane sleeves was increased in the NMDA-treated retina and non-perfused vessels were found in the injured retina. These results indicate that retinal blood vessels are damaged in the NMDA-induced retinal degeneration model. Neuronal cells may play a role in maintaining normal structure and function of the vasculature in the retina.

Research highlights▶ Intravitreal injection of NMDA induced selective damage to the inner retinal layers. ▶ Retinal blood vessels were damaged in the NMDA-treated retina. ▶ Neuronal cells may play a role in maintaining normal retinal vasculature.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 485, Issue 1, 12 November 2010, Pages 55–59
نویسندگان
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