کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4346741 1296801 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
TonEBP regulates hyperosmolality-induced arginine vasotocin gene expression in the chick (Gallus domesticus)
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
TonEBP regulates hyperosmolality-induced arginine vasotocin gene expression in the chick (Gallus domesticus)
چکیده انگلیسی

Arginine vasotocin (AVT) is expressed mainly in the paraventircular and supraoptic nuclei of the hypothalamus in chicken. This peptide is known to act as an antidiuretic hormone and its gene expression is stimulated by hyperosmolality. However, the transcription factors that regulate the AVT gene expression induced by hyperosmolality are still unknown. In this study, we examined the role of hyper-tonicity enhancer binding protein (TonEBP) in the transcriptional regulation of AVT gene in chicken. TonEBP mRNA expression levels increased at 1 h after salt-loading treatment in the hypothalamus. This increase preceded that in AVT and c-fos mRNA expression. Intracerebroventricular injections of TonEBP antisense oligonucleotides, before the salt-loading treatment, prevented the increase in AVT gene expression. These results, all together, suggest that the transcription factor TonEBP may be involved in the regulation of AVT genes expression in response to a hyperosmotic environment in chicken.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 468, Issue 3, 14 January 2010, Pages 334–338
نویسندگان
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