کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4347221 1296827 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
RNA-mediated pathogenesis in fragile X-associated disorders
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
RNA-mediated pathogenesis in fragile X-associated disorders
چکیده انگلیسی
Noncoding RNAs play important and diverse regulatory roles throughout the genome and make major contributions to disease pathogenesis. The FMR1 gene is involved in three different syndromes: fragile X syndrome (FXS), primary ovarian insufficiency (POI), and fragile X-associated tremor/ataxia syndrome (FXTAS) in older patients. Noncoding RNAs have been implicated in the molecular pathogenesis of both FXS and FXTAS. Here we will review our current knowledge on the role(s) of noncoding RNAs in FXS and FXTAS, particularly the role of the microRNA pathway in FXS and the role of noncoding riboCGG (rCGG) repeat in FXTAS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 466, Issue 2, 4 December 2009, Pages 103-108
نویسندگان
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