کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4347492 | 1296844 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Repeated cocaine exposure induces sensitization of ultrasonic vocalization in rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Repeated cocaine exposure induces sensitization of ultrasonic vocalization in rats Repeated cocaine exposure induces sensitization of ultrasonic vocalization in rats](/preview/png/4347492.png)
چکیده انگلیسی
Ultrasonic vocalization at 55Â kHz (55Â kHz-USVs) by rodents has been proposed to be a behavioral manifestation of affectively positive incentive motivation. To examine the extent to which 55Â kHz-USV emissions correlate with cocaine-induced locomotor activity, we measured cocaine-induced 55Â kHz-USVs and their relationship to cocaine-induced locomotor sensitization in rats. We demonstrate that similar to locomotor responses, 55Â kHz-USVs are also sensitized by exposure to cocaine. Furthermore, we show that the magnitude of cocaine-induced 55Â kHz-USV sensitization is positively correlated with that of locomotor sensitization. Moreover, we demonstrate that rats selectively bred for high rates of 55Â kHz-USVs exhibit higher levels of cocaine-induced 55Â kHz-USV sensitization than animals selectively bred for low levels of 55Â kHz USVs. These results suggest that the neural circuits underlying 55Â kHz-USV, which may directly reflect affective experience/motivation, can be sensitized by cocaine in a way that resembles locomotor sensitization.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 453, Issue 1, 27 March 2009, Pages 31-35
Journal: Neuroscience Letters - Volume 453, Issue 1, 27 March 2009, Pages 31-35
نویسندگان
Ping Mu, Thomas Fuchs, Daniel B. Saal, Barbara A. Sorg, Yan Dong, Jaak Panksepp,