کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4347540 1296846 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Osmolality-induced tuning of action potentials in trigeminal ganglion neurons
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Osmolality-induced tuning of action potentials in trigeminal ganglion neurons
چکیده انگلیسی
The present study explored the effect of anisotonicity on action potential (AP) in cultured trigeminal ganglion (TG) neurons. We demonstrate that the number of evoked APs was increased by both hypo- and hypertonic treatment. Transient Receptor Potential Vanilloid 4 receptor (TRPV4) activator increased the number of APs, but only hypotonic-response was markedly blocked in TRPV4−/− mice. Additionally, inhibition of PKC attenuated hypotonicity-induced increase, whereas antagonism of PKA attenuated hypertonicity-response. We conclude that anisotonicity increases excitability of nociceptors, which might be involved in anisotonicity-induced nociception. The increase of APs by hypo- and hypertonicity is mediated through different receptor and intracellular signaling pathways.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 452, Issue 1, 6 March 2009, Pages 79-83
نویسندگان
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