کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4347616 1296852 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Potential mechanisms of neuroprotection induced by low dose total-body γ-irradiation in C57 mice administered with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Potential mechanisms of neuroprotection induced by low dose total-body γ-irradiation in C57 mice administered with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
چکیده انگلیسی

Low dose total-body γ-irradiation (TBI) was reported to confer neuroprotection against MPTP-induced dopaminergic neurotoxicity. After being pretreated with a single low dose (0.5 Gy, 2.0 Gy or 3.5 Gy) TBI, C57BL/6 mice were administered with MPTP (15 mg/kg, four times, 2 h apart) intraperitoneally (i.p.). In the group pretreated with 2.0 Gy TBI, with lower lymphocytes number, neuroprotection was found by High Performance Liquid Chromatography (HPLC) determination of the striatal dopamine. Contrarily, in the group pretreated with 0.5 Gy TBI, with higher lymphocytes number, dopaminergic neuron toxicity was enhanced. So it was probably the decrease of lymphocytes, not the radiation hormesis that rendered the potential neuroprotection. And it was the balance between radiation injury and lymphocytopenia neuroprotection that decided the effect of low dose γ-irradiation on MPTP-induced dopaminergic neurotoxicity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 450, Issue 2, 30 January 2009, Pages 106–110
نویسندگان
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