کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4347960 1296870 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
CCK-8S inhibited the NMDA-activated current of cultured hippocampal neuron under normal and ethanol exposure conditions
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
CCK-8S inhibited the NMDA-activated current of cultured hippocampal neuron under normal and ethanol exposure conditions
چکیده انگلیسی
Whole-cell patch clamp technique was used to study the modulatory effect of Cholecystokin-8S (CCK-8S), a neuropeptide, on NMDA-activated current (INMDA) in cultured rat hippocampal neurons under condition of normal and ethanol exposure. Our study showed that CCK-8S inhibited INMDA in a non-concentration and non-competition dependent manner. Ethanol significantly inhibited INMDA, and CCK-8S further inhibited INMDA. Our results suggest that CCK-8S is an inhibitory modulator of NMDA receptors under normal and ethanol exposure conditions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 449, Issue 1, 2 January 2009, Pages 34-37
نویسندگان
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