کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4348070 1296876 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The bite-raised condition in aged SAMP8 mice induces dendritic spine changes in the hippocampal region
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
The bite-raised condition in aged SAMP8 mice induces dendritic spine changes in the hippocampal region
چکیده انگلیسی

The present study examined the effect of the bite-raised condition on the number of dendritic spines on hippocampal pyramidal cells in SAMP8 mice and related the results with learning ability in a water maze test. Aged mice in the bite-raised condition had reduced learning ability and a lower number of CA1 pyramidal cell dendritic spines. The results suggest that the bite-raised condition exacerbates the age-related spatial learning impairment, and that this may be due to the degeneration of hippocampal dendritic spines.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 441, Issue 2, 22 August 2008, Pages 141–144
نویسندگان
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