کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4348389 | 1296888 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Midbrain serotonin and striatum dopamine transporter binding in double depression: A one-year follow-up study
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Data on neurobiological differences between major depression (MD) and double depression (DD) are scarce. We examined the striatum dopamine (DAT) and midbrain serotonin transporter (SERT) binding of [123I] nor-β-CIT in DD patients (n = 8) and compared it to that in MD patients (n = 11) and healthy controls (n = 19). Drug-naïve patients and controls were imaged by single-photon emission computed tomography at baseline, and the patients also after one year of psychodynamic psychotherapy. Both DD and MD groups had lower midbrain [123I] nor-β-CIT binding compared with the controls. Baseline 17-item Hamilton Depression Rating Scale (HAM-D-17) scores significantly decreased in both groups after one year of psychotherapy (DD: t = 3.55, p = 0.009; MD: t = 5.86, p < 0.001). No differences between the DD and MD groups were observed in age-adjusted baseline striatum or midbrain [123I] nor-β-CIT binding or its change during psychotherapy. Age-adjusted baseline striatum [123I] nor-β-CIT binding correlated inversely with the duration of both dysthymia (rho = â0.76, p = 0.03) and MD (rho = â0.83, p = 0.01) in the DD group. No such finding was observed in the MD group (rho = 0.26, p = 0.44). Baseline HAM-D-17 did not correlate with the change in striatum or midbrain [123I] nor-β-CIT binding in either group. In conclusion, our findings suggest that when using midbrain [123I] nor-β-CIT binding as a marker of SERT binding, no differences are detectable between patients with DD and MD. However, low striatum [123I] nor-β-CIT binding, a marker of DAT binding, may be associated with a longer illness duration in dysthymia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 441, Issue 3, 29 August 2008, Pages 291-295
Journal: Neuroscience Letters - Volume 441, Issue 3, 29 August 2008, Pages 291-295
نویسندگان
Soili M. Lehto, Tommi Tolmunen, Jyrki Kuikka, Minna Valkonen-Korhonen, Mikko Joensuu, Pirjo I. Saarinen, Ritva Vanninen, Pasi Ahola, Jari Tiihonen, Johannes Lehtonen,