کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4348511 1296893 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sympathetic overactivity and plasma leptin levels in Rett syndrome
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Sympathetic overactivity and plasma leptin levels in Rett syndrome
چکیده انگلیسی
Rett syndrome (RTT) is a severe developmental-neurological disorder, characterized by profound and progressive loss of intellectual functioning, occurring after a period (of at least 6 months) of normal development with classic stereotype hand movements, gait ataxia, jerky truncal ataxia, deceleration of brain and body organ growth and cardiac dysautonomia. Pathogenesis of sympathetic overactivity in RTT is unknown, but a previous study observed increased plasma leptin levels in Rett girls and it is well known the role of leptin in the regulation of sympathetic nervous system activity. Aim of our study is to evaluate a relationship between plasma leptin levels and sympathetic activity in RTT. Thirty-two female patients (12.1 ± 6.3 years), affected by RTT were enrolled in the study. In all the subjects, we analyzed heart rate variability, QT corrected interval and plasma leptin levels. A significant correlation was found between plasma leptin levels and LF/HF (expression of sympatho-vagal balance) (Spearman r = 0.44, p = 0.001). There is also a significant negative correlation between HF component (expression of vagal activity) and plasma leptin levels (Spearman r = −0.037, p = 0.03) and a positive correlation between LF component and plasma leptin levels (Spearman r = 0.047, p = 0.01). These results show that in RTT higher plasma leptin levels appear to be associated with sympathetic overactivity, suggesting a role for leptin in cardiac dysautonomia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 432, Issue 1, 13 February 2008, Pages 69-72
نویسندگان
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