کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4348845 1615180 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
CSF histamine levels in rats reflect the central histamine neurotransmission
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
CSF histamine levels in rats reflect the central histamine neurotransmission
چکیده انگلیسی

Reduced cerebrospinal fluid (CSF) histamine levels were found in human hypersomnia. To evaluate the functional significance of changes in CSF histamine levels, we measured the levels in rats across 24 h, after the administration of wake-promoting compounds modafinil, amphetamine, and thioperamide, and after sleep deprivation and food deprivation. Thioperamide significantly increased CSF histamine levels with little effects on locomotor activation. Both modafinil and amphetamine markedly increased the locomotor activity, but had no effects on histamine. The levels are high during active period and are markedly elevated by sleep deprivation, but not by food deprivation. Our study suggests that CSF histamine levels in rats reflect the central histamine neurotransmission and vigilance state changes, providing deeper insight into the human data.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 430, Issue 3, 17 January 2008, Pages 224–229
نویسندگان
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