کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4349004 | 1296918 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Association between neprilysin polymorphisms and sporadic Alzheimer's disease
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Association between neprilysin polymorphisms and sporadic Alzheimer's disease Association between neprilysin polymorphisms and sporadic Alzheimer's disease](/preview/png/4349004.png)
چکیده انگلیسی
The deposition of amyloid beta peptide (Aβ) in the form of plaques in the brain is a hallmark of Alzheimer's disease (AD). Neprilysin is the major Aβ-degradating enzyme and reduction in neprilysin activity could contribute to Alzheimer's by increasing the steady-state level of Aβ. To provide further evidence for the role of neprilysin in AD we genotyped 22 polymorphisms, 21 SNPs and the GT repeat in the promoter region, across the neprilysin gene in 298 Caucasian sporadic Alzheimer's patients and 298 age-matched controls. Several SNPs showed genotypic and allelic association to AD. SNP rs1836915, in linkage disequilibrium block 2, showed the greatest extent of genotypic association with AD (p = 0.0076). We were unable to replicate any of the SNPs that were previously reported as putatively associated with AD. However, these novel findings add to the weight of evidence supporting the involvement of neprilysin in the aetiology of Alzheimer's disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 427, Issue 2, 5 November 2007, Pages 103-106
Journal: Neuroscience Letters - Volume 427, Issue 2, 5 November 2007, Pages 103-106
نویسندگان
Linda S. Wood, Eve H. Pickering, Duncan McHale, Bryan M. Dechairo,