کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4349047 1296920 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preconditioning ischemia attenuates increased neurexin–neuroligin1–PSD-95 interaction after transient cerebral ischemia in rat hippocampus
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Preconditioning ischemia attenuates increased neurexin–neuroligin1–PSD-95 interaction after transient cerebral ischemia in rat hippocampus
چکیده انگلیسی

In this study, we investigated the interactions between synapse adhesion molecules neurexin, neuroligin1, neuroligin2 and postsynaptic density protein 95 (PSD-95) in transient cerebral ischemia and possible regulatory mechanism of these interactions. Our data show that preconditioning ischemia can down-regulate the increased neurexin–neuroligin1–PSD-95 interaction induced by ischemia injury and exerts a neuroprotective effect. Pre-treatment of N-methyl-d-aspartate (NMDA) receptor antagonist ketamine can demolish this neuroprotective effect of preconditioning by increasing neurexin–neuroligin1–PSD-95 interaction. These results indicate that the neurexin–neuroligin1–PSD-95 is an important signalling module in ischemic injury and a novel possible target in therapeutics of brain ischemia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 426, Issue 3, 22 October 2007, Pages 192–197
نویسندگان
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