کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4349088 1296923 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Decreased gene expression of neuropeptide Y and its receptors in hippocampal regions during ethanol withdrawal in rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Decreased gene expression of neuropeptide Y and its receptors in hippocampal regions during ethanol withdrawal in rats
چکیده انگلیسی

Ethanol withdrawal is associated with neuronal hyperexcitability and increased hippocampal glutamate release. Neuropeptide Y (NPY) appears to play an important role in regulation of hippocampal neuronal excitability by inhibiting glutamate release. Expression of NPY and its receptors Y1, Y2, and Y5 was studied in hippocampal areas of rats during ethanol withdrawal after repeated intragastric ethanol administration for 2 or 4 days using in situ hybridization. Withdrawal was associated with decreased hippocampal expression of NPY and each of its receptors, particularly Y2, after 2 and/or 4 days of ethanol compared to control rats. These data suggest that the hippocampal NPY system is downregulated during ethanol withdrawal and these neuroadaptational changes could play a role in mediating withdrawal hyperexcitability.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 424, Issue 3, 13 September 2007, Pages 160–164
نویسندگان
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