کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4349369 | 1296938 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lrrk2 mutations in South America: A study of Chilean Parkinson's disease
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Pathogenic substitutions in the leucine-rich repeat kinase 2 protein (Lrrk2), R1441G and G2019S, are a prevalent cause of autosomal dominant and sporadic Parkinson's disease in the Northern Spanish population. In this study we examined the frequency of these two substitutions in 166 Parkinson's disease patients and 153 controls from Chile, a population with Spanish/European-Amerindian admixture. Lrrk2 R1441G was not observed, however Lrrk2 G2019S was detected in one familial and four sporadic Parkinson's disease patients. These findings suggest Lrrk2 G2019S may play an important role in Parkinson's disease on the South American Continent and further studies are now warranted.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 422, Issue 3, 18 July 2007, Pages 193–197
Journal: Neuroscience Letters - Volume 422, Issue 3, 18 July 2007, Pages 193–197
نویسندگان
Carolina Perez-Pastene, Stephanie A. Cobb, Fernando Díaz-Grez, Mary M. Hulihan, Marcelo Miranda, Pablo Venegas, Osvaldo Trujillo Godoy, Jennifer M. Kachergus, Owen A. Ross, Luis Layson, Matthew J. Farrer, Juan Segura-Aguilar,