کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4349911 | 1296963 | 2007 | 4 صفحه PDF | دانلود رایگان |

We investigated cerebrospinal fluid (CSF) samples from 21 patients with idiopathic normal pressure hydrocephalus (INPH) and 14 controls without neurological disease. The concentrations of leucine-rich α-2-glycoprotein (LRG), transforming growth factor (TGF)-β1, 2, 3 and TGF-β type II receptor (TβR-II) in CSF were measured using ELISA. TGF-β1, TβR-II and LRG CSF levels of patients with INPH were significantly higher than controls, whereas no significant differences in TGF-β2 levels were found between INPH patients and controls. The present study suggests that TGF-βs expressions may be modulated differently in patients with INPH. These results also indicate that the CSF level assay of TGF-β1, TβR-II and LRG is useful for the diagnosis of patients with INPH, and TGF-β1, TβR-II and LRG may be involved in the pathogenesis of the disease.
Journal: Neuroscience Letters - Volume 413, Issue 2, 14 February 2007, Pages 141–144