کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4349953 1296965 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chromogranin A activates diverse pathways mediating inducible nitric oxide expression and apoptosis in primary microglia
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Chromogranin A activates diverse pathways mediating inducible nitric oxide expression and apoptosis in primary microglia
چکیده انگلیسی
Chromogranin A (CgA) is associated with microglial activation cascades implicated in neurodegeneration in Alzheimer's, Pick's and Parkinson's diseases. In primary rat microglia, CgA-mediated inducible nitric oxide (iNOS) expression, nitric oxide (NO) production, mitochondrial depolarisation and apoptosis were inhibited by PP2 (Src kinase inhibitor). CgA-mediated iNOS expression and NO production were also inhibited by U0126 (MEK inhibitor), but mitochondrial depolarisation and apoptosis were not. PP2 inhibited ERK phosphorylation; therefore, Src mediates CgA-induced ERK phosphorylation leading to iNOS expression and NO production. Glutamate release induced by CgA was independent of both pathways. These findings provide insights into the way microglia are activated by CgA and the microglial signalling mechanisms associated with neurological disorders such as Alzheimer's disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 413, Issue 3, 21 February 2007, Pages 227-232
نویسندگان
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