کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4350293 | 1615187 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of the 5-HT7 receptor antagonist SB-269970 on rat hormonal and temperature responses to the 5-HT1A/7 receptor agonist 8-OH-DPAT
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The physiological function of 5-HT7 receptors is not yet fully determined. This study was designed to characterize the involvement of 5-HT7 receptor in rat body temperature regulation and in adrenocorticotropic hormone (ACTH) and corticosterone secretion. In the first part of our study, acute administration of SB-269970 (0.1-1Â mg/kg, i.p.), a potent and selective 5-HT7 receptors antagonist, dose-dependently prevented 5-HT1A/7 receptor agonist 8-OH-DPAT (0.1Â mg/kg, s.c.)-induced hypothermia and when the 5-HT1A receptor antagonist WAY-100,635 was co-injected with SB-269970, a reduction of the latter hypothermia was obtained in an additive manner. In contrast, 1Â mg/kg (i.p.) of SB-269970 failed to prevent 8-OH-DPAT (0.5Â mg/kg, s.c.)-induced increase of ACTH and corticosterone plasma levels. In conclusion, the present results unveil an additive effect of both 5-HT1A and 5-HT7 receptors in core body temperature regulation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 404, Issues 1â2, 14 August 2006, Pages 122-126
Journal: Neuroscience Letters - Volume 404, Issues 1â2, 14 August 2006, Pages 122-126
نویسندگان
Céline Faure, Ouissame Mnie-Filali, Hélène Scarna, Guy Debonnel, Nasser Haddjeri,