کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4350431 | 1296985 | 2006 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differential suppression of endotoxin-inducible inflammatory cytokines by nuclear factor kappa B (NFκB) inhibitor in rat microglia
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
The molecular mechanism by which the deleterious cytokines interleukin 1 beta (IL-1β) and tumor necrosis factor alpha (TNFα) are induced in endotoxin-stimulated microglia was investigated from the viewpoint of signal transduction. Neither cytokine is produced in nonstimulated rat microglia, but both are remarkably induced by stimulation with endotoxin lipopolysaccharide (LPS). LPS-inducible IL-1β was significantly suppressed by pretreatment with the nuclear factor kappa B (NFκB) inhibitor ammonium pyrrolidine dithiocarbamate (APDC), but TNFα was not. APDC was actually confirmed to suppress the degradation of IκBα and IκBβ in microglia, indicating a role for the inhibitor of NFκB activation. Taken together, these results suggest that the induction of IL-1β and TNFα in endotoxin-stimulated microglia is differentially regulated at the level of NFκB activation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 401, Issue 3, 3 July 2006, Pages 199-202
Journal: Neuroscience Letters - Volume 401, Issue 3, 3 July 2006, Pages 199-202
نویسندگان
Kazuyuki Nakajima, Yuichi Matsushita, Yoko Tohyama, Shinichi Kohsaka, Tadashi Kurihara,