کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4350440 | 1296985 | 2006 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Expression of the α1A-adrenergic receptor in schizophrenia
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
The α1-adrenergic receptors may contribute to cognitive functions relevant to schizophrenia. Following the discovery of an association between polymorphisms in the regulatory region of the α1A-adrenergic receptor and schizophrenia we investigated the expression of mRNA for this receptor between schizophrenics (n = 19) and controls (n = 19) using a TaqMan approach in post-mortem brains. No differences were found suggesting that mRNA levels are not altered in schizophrenia. Genotypic data for the subjects found that possession of the previously associated genotypes did not convey a difference in mRNA expression suggesting that these polymorphisms do not affect the level of transcription.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 401, Issue 3, 3 July 2006, Pages 248–251
Journal: Neuroscience Letters - Volume 401, Issue 3, 3 July 2006, Pages 248–251
نویسندگان
Dan A. Clark, Dalu Mancama, Robert W. Kerwin, Maria J. Arranz,