کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4351417 | 1615295 | 2014 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chronic social instability stress enhances vulnerability of BDNF response to LPS in the limbic structures of female rats: A protective role of antidepressants
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کلمات کلیدی
GAPDHCSISIL-1βCREBIL-6LPS5-HT5-hydroxytryptamine, serotonin - 5-hydroxytryptamine، serotoninBDNF - BDNF یا فاکتور نورونزایی مشتقشده از مغز interleukin-6 - اینترلوکین ۶Interleukin-1β - اینترلوکین-1βAntidepressants - داروهای ضد افسردگیCNS - دستگاه عصبی مرکزیcentral nervous system - سیستم عصبی مرکزیbrain derived neurotrophic factor - عامل مغز استخوان مغز استخوان استlipopolysaccharide - لیپوپلی ساکاریدFemale rats - موش صحراییcAMP response element-binding protein - پروتئین واکنش القا کننده واکنش cAMPglyceraldehyde 3-phosphate dehydrogenase - گلیسرولیدید 3-فسفات دهیدروژنازglucocorticoid receptor - گیرنده گلوکوکورتیکوئید
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Chronic social instability stress enhances vulnerability of BDNF response to LPS in the limbic structures of female rats: A protective role of antidepressants Chronic social instability stress enhances vulnerability of BDNF response to LPS in the limbic structures of female rats: A protective role of antidepressants](/preview/png/4351417.png)
چکیده انگلیسی
The aim of the present study was to estimate the influence of antidepressants given chronically on brain-derived neurotrophic factor (BDNF) alterations induced by lipopolysaccharide (LPS) in the amygdala and hippocampus of female rats subjected to chronic social instability stress (CSIS) for 29-30 days. CSIS was used as a paradigm known to be more stressful for females because stress induces affective disorders more frequently in women than men. An increased relative adrenal weight and a tendency towards the enhanced plasma corticosterone concentration were found in the stressed rats. Sucrose preference was not changed. On the last experimental day, the rats in the estrus phase were injected ip with LPS (1Â mg/kg). In the stressed rats, LPS administration decreased BDNF mRNA levels in both limbic structures. Desipramine (10Â mg/kg), fluoxetine (5Â mg/kg) or tianeptine (10Â mg/kg) given ip once daily reversed the effect of the combined stress and LPS, and tianeptine induced the strongest effects. These results indicate that chronic stress enhances vulnerability of BDNF response to deleterious influence of neuroinflammation in the examined limbic structures, what may account for its role in triggering neuropsychiatric diseases. The observed effect of antidepressants may be of significance for their therapeutic effects in the stress-induced affective disorders in females.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volume 88, November 2014, Pages 74-83
Journal: Neuroscience Research - Volume 88, November 2014, Pages 74-83
نویسندگان
Marta M. Nowacka, Monika Paul-Samojedny, Anna M. Bielecka, Ewa Obuchowicz,