کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4351542 | 1298061 | 2013 | 4 صفحه PDF | دانلود رایگان |
• Expression patterns of olfactory cells are similar to developing brain cells.
• Blood cells are different from brain cells in regard to expression patterns.
• Olfactory cells can be used a peripherally accessible surrogate system.
Human olfactory cells obtained by rapid nasal biopsy have been suggested to be a good surrogate system to address brain disease-associated molecular changes. Nonetheless, whether use of this experimental strategy is justified remains unclear. Here we compared expression profiles of olfactory cells systematically with those from the brain tissues and other cells. Principal component analysis indicated that the expression profiles of olfactory cells are very different from those of blood cells, but are closer to those of stem cells, in particular mesenchymal stem cells, that can be differentiated into the cells of the central nervous system.
Journal: Neuroscience Research - Volume 77, Issue 4, December 2013, Pages 247–250