کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4352349 | 1298108 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
MR tracking of transplanted glial cells using poly-l-lysine-CF3
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Magnetic resonance (MR) imaging using super-paramagnetic iron oxides (SPIOs) is a powerful tool to monitor transplanted cells in living animals. Since, however, SPIOs are negative contrast agents, positive agents have been explored. In this study, we examined the feasibility of FITC-labeled poly-l-lysine-CF3 (PLK-CF3) using glial cells. FITC-labeled PLK-CF3 was easily internalized by neuroblastoma cells and glia as adding it into culture medium. No toxicity was seen at the concentration of less than 80 μg/ml. MR images positively detected labeled cells transplanted in the brain of living mouse. The results indicate that FITC-labeled PLK-CF3 is a useful positive contrast agent for MR tracking.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volume 56, Issue 2, October 2006, Pages 224–228
Journal: Neuroscience Research - Volume 56, Issue 2, October 2006, Pages 224–228
نویسندگان
Chiaki Masuda, Zyunichi Maki, Shigehiro Morikawa, Masahito Morita, Toshiro Inubushi, Yoshitaka Matsusue, Sonoko Yamagata, Hiroyasu Taguchi, Yukio Doi, Nobuaki Shirai, Koichi Hirao, Ikuo Tooyama,