کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4353195 | 1298208 | 2006 | 6 صفحه PDF | دانلود رایگان |
Changes in synaptic efficacy at the parallel fiber (PF)–Purkinje cell (PC) synapse are postulated to be a cellular basis for motor learning. Although long-term efficacy changes lasting more than an hour at this synapse, i.e., long-term potentiation and depression, have been extensively studied, relatively short lasting synaptic efficacy changes, namely short-term potentiation (STP) lasting for tens of minutes, have not been discussed to date. Here we report that this synapse shows an apparent STP reliably by a periodic burst pattern of homosynaptic stimulation. This STP is presynaptically expressed, since it accompanies with a reduced paired-pulse facilitation and is resistant to postsynaptic Ca2+ reduction by BAPTA injection or in P/Q-type Ca channel knockout cerebella. This novel type of synaptic plasticity at the PF–PC synapse would be a clue for understanding the presynaptic mechanisms of plasticity at this synapse.
Journal: Neuroscience Research - Volume 55, Issue 1, May 2006, Pages 28–33