کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4353561 1298475 2011 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The prefrontal–limbic network in depression: A core pathology of synapse regression
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
The prefrontal–limbic network in depression: A core pathology of synapse regression
چکیده انگلیسی

Grey matter loss occurs in different components of the prefrontal–limbic network (PLN) implicated in major depressive disorder (MDD). This must be accounted for by specific pathologies of cells and their processes that comprise the grey matter. In order to identify these a quantitative evaluation of the contributions of neurons, glial cells, blood vessels and extracellular space to the grey matter volume is determined. This forms the basis of evaluating the various claims that the core pathology of certain cell types and/or their processes are responsible for the grey matter loss. It is concluded that it is the loss of synapses and concomitantly that of the dendrites on which they normally impinge that accounts quantitatively for the major loss of grey matter in different components of the PLN in depression.


► Grey matter loss occurs in the prefrontal–limbic network (PLN) in mood disorders.
► This must be accounted for by pathologies of cells in the grey matter.
► The contributions of different cell classes to grey matter volume is determined.
► Which cell or their processes are responsible for the grey matter loss?
► Loss of synapses and their dendrites accounts for the loss of grey matter.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neurobiology - Volume 93, Issue 4, April 2011, Pages 457–467
نویسندگان
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