کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4354237 1299032 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neuronal gap junctions: making and breaking connections during development and injury
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Neuronal gap junctions: making and breaking connections during development and injury
چکیده انگلیسی

In the mammalian central nervous system (CNS), coupling of neurons by gap junctions (i.e., electrical synapses) and the expression of the neuronal gap junction protein, connexin 36 (Cx36), transiently increase during early postnatal development. The levels of both subsequently decline and remain low in the adult, confined to specific subsets of neurons. However, following neuronal injury [such as ischemia, traumatic brain injury (TBI), and epilepsy], the coupling and expression of Cx36 rise. Here we summarize new findings on the mechanisms of regulation of Cx36-containing gap junctions in the developing and mature CNS and following injury. We also review recent studies suggesting various roles for neuronal gap junctions and in particular their role in glutamate-mediated neuronal death.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 36, Issue 4, April 2013, Pages 227–236
نویسندگان
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