Stable release of BDNF from the fibroblast cell line NIH3T3 grown on silicone elastomers enhances survival of spiral ganglion cells in vitro and in vivo

► Cell-mediated BDNF release from silicone elastomers in vitro and in vivo. ► Spiral ganglion neuron survival in vitro and spiral ganglion neuron density in deafened guinea pigs assessed. ► Increased neuronal survival in vitro and in vivo with cell-based BDNF treatment compared to controls.