Receptors for leptin in the otic labyrinth and the cochlear-vestibular nerve of guinea pig are modified in hormone-induced anorexia

► Leptin is one of several adipocyte hormones involved in energy balance. ► Leptin has a major role in bone metabolism and has different effects on myelin. ► We find leptin receptors within the pathological otic capsule. ► We find leptin receptors in the healthy cochlear-vestibular nerve. ► The leptin receptors associated with the ear are modified in anorexia.