کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4355890 | 1615650 | 2009 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The effects of acoustic environment after traumatic noise exposure on hearing and outer hair cells
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کلمات کلیدی
FITCAugmented acoustic environmentOHCNIHLAAEDADGSSGGSHAcoustic trauma - آسیب آکوستیکdiode array detector - آشکارساز آرایه دیودHearing loss - از دست دادن شنواییnoise-induced hearing loss - افت شنوایی ناشی از سر و صداDae - دلمOuter hair cells - سلول های موی بیرونیfluorescein isothiocyanate - فلوئورسین ایسوتیوسیاناتChinchilla - چینچیلاreduced glutathione - کاهش گلوتاتیونhigh-performance liquid chromatography - کروماتوگرافی مایعی کاراHPLC - کروماتوگرافی مایعی کاراGlutathione - گلوتاتیونoxidized glutathione - گلوتاتیون اکسید شده
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
سیستم های حسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Previous studies reported that exposure to non-traumatic level sounds after traumatic noise exposure reduced the degree of noise-induced hearing loss and hair cell stereocilia damage. The current study investigated the effects of a 3-day post-noise acoustic environment on the degree of noise-induced hearing loss and cochlear damage. Female chinchillas were exposed to traumatic continuous noise (4 kHz octave-band noise) at 107 dB SPL for 1 h and then placed in either an augmented acoustic environment (AAE) or deprived acoustic environment (DAE) for 3 days. The AAE group was exposed to a broad-band noise (4-20 kHz) at 80 dB SPL and the DAE animals were fit with conventional earplugs to minimize the level of acoustic stimulation. Auditory brainstem responses (ABRs) were recorded before and 3 days after the traumatic noise exposure. The AAE group showed a significantly lower average threshold shift at the frequencies of 4 and 8 kHz (p < 0.01). Correspondingly, significantly fewer missing and dying outer hair cells (OHCs) were observed in the AAE group than in the DAE group. Although the cochlear reduced and oxidized glutathione levels (GSH and GSSG, respectively) were essentially the same in two groups at day 3, significant correlations were found between GSSG levels and mean ABR threshold shift (1-16 kHz) in the AAE group; as well as GSSG and percentage of total OHC loss in the DAE group. The results suggest that post-noise acoustic environment influenced the degree of hearing loss and OHC deterioration after traumatic noise exposure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hearing Research - Volume 250, Issues 1â2, April 2009, Pages 10-18
Journal: Hearing Research - Volume 250, Issues 1â2, April 2009, Pages 10-18
نویسندگان
Chiemi Tanaka, Guang-Di Chen, Bo Hua Hu, Lai-Har Chi, Manna Li, Guiliang Zheng, Eric C. Bielefeld, Samson Jamesdaniel, Donald Coling, Donald Henderson,