کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4356328 1615673 2007 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mechanisms of cisplatin-induced ototoxicity and prevention
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی سیستم های حسی
پیش نمایش صفحه اول مقاله
Mechanisms of cisplatin-induced ototoxicity and prevention
چکیده انگلیسی

Cisplatin is a widely used chemotherapeutic agent to treat malignant disease. Unfortunately, ototoxicity occurs in a large percentage of patients treated with higher dose regimens. In animal studies and in human temporal bone investigations, several areas of the cochlea are damaged, including outer hair cells in the basal turn, spiral ganglion cells and the stria vascularis, resulting in hearing impairment. The mechanisms appear to involve the production of reactive oxygen species (ROS), which can trigger cell death. Approaches to chemoprevention include the administration of antioxidants to protect against ROS at an early stage in the ototoxic pathways and the application of agents that act further downstream in the cell death cascade to prevent apoptosis and hearing loss. This review summarizes recent data that shed new light on the mechanisms of cisplatin ototoxicity and its prevention.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hearing Research - Volume 226, Issues 1–2, April 2007, Pages 157–167
نویسندگان
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