کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4359211 1300490 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Involvement of the Pta-AckA pathway in protein folding and aggregation
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Involvement of the Pta-AckA pathway in protein folding and aggregation
چکیده انگلیسی

Acetyl phosphate is a central metabolite involved in a broad range of versatile cellular functions. Recently it was observed that in Escherichia coli the acetyl phosphate pathway is required for efficient ATP-dependent proteolysis. Deletion of the operon coding for acetyl phosphate metabolism (ΔackApta) results in a very low cytoplasmic level of acetyl phosphate and impaired proteolysis. Here we show that the ΔackApta mutation affects additional components of the protein quality control system. Thus, this deletion is accompanied by a decrease in protein refolding and rescue from aggregates. These results indicate the involvement of the acetyl phosphate pathway in chaperone capabilities, in addition to their effect on proteolysis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Research in Microbiology - Volume 160, Issue 1, January–February 2009, Pages 80–84
نویسندگان
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