کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4359493 | 1615930 | 2008 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Phylogenetic comparison of the known Chlamydia trachomatis Ï66 promoters across to Chlamydia pneumoniae and Chlamydia caviae identifies seven poorly conserved promoters
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We used four different phylogenetic footprinting programs and the six chlamydial species with publicly available whole genome sequences to analyze the 12 known Ï66 promoters of Chlamydia trachomatis that phylogenetically footprinted negative in our previous paper. The analysis showed that 7 of the 12 promoters were poorly conserved across C. trachomatis, Chlamydia pneumoniae and Chlamydia caviae. Interestingly, the associated gene sets for these seven promoters were homologs and the gene orders were well conserved across these three species. Additional phylogenetic footprinting, across different subsets from that used above, of the six publicly available whole chlamydial genome sequences and transcription initiation site mapping of chlamydial promoters was also performed. This analysis showed that two of the seven poorly conserved promoters, the promoters in the upstream regions of C. caviae ltuA and ltuB, were like Escherichia coli Ï70 promoters. Therefore, these promoters are similar to the promoters of C. trachomatis ltuA and ltuB, as they are Ï70-like. Given the fact that 7 out of the 22 known Ï66 promoters in C. trachomatis are poorly conserved across C. trachomatis, C. pneumoniae and C. caviae, we would like to suggest that many other chlamydial promoters are poorly conserved across these species.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Research in Microbiology - Volume 159, Issues 7â8, SeptemberâOctober 2008, Pages 550-556
Journal: Research in Microbiology - Volume 159, Issues 7â8, SeptemberâOctober 2008, Pages 550-556
نویسندگان
Brian Grech, Sarah Mathews, Peter Timms,