کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4365952 | 1301793 | 2008 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Barbiturate-induced increase of biocatalytic hydroxylation and N-dealkylation of N,N-diethylaniline by whole-cell incubation with Bacillus megaterium
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
علوم زیست محیطی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Barbiturate-induced increase of biocatalytic hydroxylation and N-dealkylation of N,N-diethylaniline by whole-cell incubation with Bacillus megaterium Barbiturate-induced increase of biocatalytic hydroxylation and N-dealkylation of N,N-diethylaniline by whole-cell incubation with Bacillus megaterium](/preview/png/4365952.png)
چکیده انگلیسی
Bacillus megaterium was used in biotransformation studies to test the influence of several barbiturates towards the recently observed N-dealkylation and arylic hydroxylation of N,N-diethylaniline. Certain barbiturates (phenobarbital and amobarbital) induced increased enzyme activity in whole-cell incubations with B. megaterium resulting in an increasing amount of N-deethylated and hydroxylated arylic (ortho- and para-hydroxylation) products, whereas ortho-hydroxylation was slightly favored. Phenobarbital did not show any effects towards hydroxylation activity, but N-dealkylation activity was highly induced. Finally, metyrapone highly reduced hydroxylation and N-dealkylation activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Biodeterioration & Biodegradation - Volume 61, Issue 3, April 2008, Pages 272–277
Journal: International Biodeterioration & Biodegradation - Volume 61, Issue 3, April 2008, Pages 272–277
نویسندگان
Marcus Taupp, Frank Heckel, Dag Harmsen, Peter Schreier,