Spinigerin induces apoptotic like cell death in a caspase independent manner in Leishmania donovani

- Annexin-V positive and TUNEL positive cells observed upon spinigerin exposure.
- ROS machinery was involved in spinigerin mediated apoptosis like death.
- Mitochondrial membrane potential was collapsed without caspase like activity.
- The infection rate was reduced by 20% upon exposure to 150 μM spinigerin.
- Computational analysis suggests spiningerin interacts with trypanothione reductase.