کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4371220 | 1302502 | 2010 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Leishmania major: Disruption of signal peptidase type I and its consequences on survival, growth and infectivity
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
انگل شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Leishmania major: Disruption of signal peptidase type I and its consequences on survival, growth and infectivity Leishmania major: Disruption of signal peptidase type I and its consequences on survival, growth and infectivity](/preview/png/4371220.png)
چکیده انگلیسی
The obtained heterozygote mutant by disrupting one allele of SPase I in L. major showed significantly reduced level of infectivity in bone marrow-derived macrophages. In addition, the heterozygote mutants are unable to cause cutaneous lesion in susceptible BALB/c mice. This is the first report showing that SPase I may have an important role in Leishmania infectivity, e.g. in differentiation and survival of amastigotes. Apparently, the SPase I expression is not essential for in vitro growth of the parasite.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Parasitology - Volume 126, Issue 2, October 2010, Pages 135-145
Journal: Experimental Parasitology - Volume 126, Issue 2, October 2010, Pages 135-145
نویسندگان
Tahereh Taheri, Ali-Hatef Salmanian, Elham Gholami, Fatemeh Doustdari, Farnaz Zahedifard, Sima Rafati,