کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4371370 1302514 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of amphotericin B on the infection success of Schistosoma mansoni in Biomphalaria glabrata
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی انگل شناسی
پیش نمایش صفحه اول مقاله
Effect of amphotericin B on the infection success of Schistosoma mansoni in Biomphalaria glabrata
چکیده انگلیسی

In the present study, we examined the effect of amphotericin B on larval stages (miracidia and primary sporocyst) of the helminth Schistosoma mansoni, the causative agent of human schistosomiasis. Amphotericin B (AmB) is a polyene macrolide that disturbs the function of the cell membrane; it is widely used as prophylactic antimycotic agent in in vitro culture. We show for the first time that S. mansoni miracidia infectivity is considerably reduced after AmB treatment. Moreover we demonstrate that AmB does not affect the development, growth, viability, and behavior of miracidia and primary sporocysts. Our data indicate that AmB effects on S. mansoni sporocyst prevalence are linked to the oxidative properties of AmB. These may alter the capacity of sporocysts to respond to the oxidative stress generated by the snail immune defence system.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Parasitology - Volume 125, Issue 2, June 2010, Pages 70–75
نویسندگان
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