کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4406643 | 1618691 | 2013 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In vitro trials of some antimicrobial combinations against Staphylococcus aureus and Pseudomonas aeruginosa
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کلمات کلیدی
P. aeruginosaMICFICI - FICMRSA - استافیلوکوک اورئوس مقاوم به متی سیلین یا MRSA Methicillin resistant Staphylococcus aureus - استافیلوکوک اورئوس مقاوم به متیسیلینS. aureus - استافیلوکوکوس اورئوسMinimum inhibitory concentration - حداقل غلظت مهاریFractional inhibitory concentration index - شاخص غلظت مهار کننده مکررAntimicrobial - ماده ضد میکروبی یا آنتی میکروبیالSynergism - همکاری
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بوم شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: In vitro trials of some antimicrobial combinations against Staphylococcus aureus and Pseudomonas aeruginosa In vitro trials of some antimicrobial combinations against Staphylococcus aureus and Pseudomonas aeruginosa](/preview/png/4406643.png)
چکیده انگلیسی
Staphylococcus aureus and Pseudomonas aeruginosa are rapidly increasing as multidrug resistant strains worldwide. In nosocomial settings because of heavy exposure of different antimicrobials, resistance in these pathogens turned into a grave issue in both developed and developing countries. The aim of this study was to investigate in vitro antibiotic synergism of combinations of β-lactam-β-lactam and β-lactam-aminoglycoside against clinical isolates of S. aureus and P. aeruginosa. Synergy was determined by checkerboard double dilution method. The combination of amoxicillin and cefadroxil was found to be synergistic against 47 S. aureus isolates, in the FICI range of 0.14-0.50 (81.03%) followed by the combination of streptomycin and cefadroxil synergistic against 44 S. aureus isolates in the FICI range of 0.03-0.50 (75.86%). The combination of streptomycin and cefadroxil was observed to be synergistic against 39 P. aeruginosa isolates in the FICI range of 0.16-0.50 (81.28%). Further actions are needed to characterize the possible interaction mechanism between these antibiotics. Moreover, the combination of streptomycin and cefadroxil may lead to the development of a new and vital antimicrobial against simultaneous infections of S. aureus and P. aeruginosa.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Saudi Journal of Biological Sciences - Volume 20, Issue 1, January 2013, Pages 79-83
Journal: Saudi Journal of Biological Sciences - Volume 20, Issue 1, January 2013, Pages 79-83
نویسندگان
Zafar Ahmed, Shaukat Saeed Khan, Mahnaaz Khan,